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Madame Jo-Ann Python (ジョアン・パイソン Joan Paison?) is a member of S.U.L.F.U.R. who comes from the kingdom of Hope. She is the member who first contacted King Anthony and told him of the Millennium Gummies. She has a high intellect and is a childhood friend of Madame Smith, one of her colleagues. During Diablo's War, through long work, she discovered that the Prophecy predicted the date for the End of the World to be during Diablo's War. She later died during the End of the World. After the Reconstruction of the World, she gets married to Bob Golf.

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